633 Comparison of soluble proteins from skin sections of acne and TCA induced postinflammatory hyperpigmentation and erythema

Postinflammatory hyperpigmentation (PIH) is an acquired hypermelanosis occurring after cutaneous inflammation or injury that can arise in all skin types, but more frequently affects skin-of-color. The differences the ethology of PIH and erythema (PIE) color were evaluated from soluble protein extracts collected section samples, using Somascan kit1.3 k (n=5). samples selected gluteal TCA-induced lesions truncal acne pustules, either PIE, at day 28 post initial evaluation. Differences between proteins (FDR<0.05) PIE analyzed with STRING version 11.5 analysis points toward involvement JAK/STAT signaling pathway enhanced IL17 compared to (OSM, CSF3, IL10RA, IL12RB2, IL10RB, IL3, CSF2, IL17D, IL17F, IFNA2, IFNA10, CRLF2, IL5RA, TYK2, IL12RB1, PRLR, GHR). has been described for some chronic inflammatory conditions acne. A higher occurrence dermal remodeling proteases inhibitors found (MMP1, MMP2, MMP7, TIMP2) indicating a phase time excision. Concurrently, elevated levels IL-1β, TGF-β (critical triggering continuing differentiation programs naïve CD4+ T cells IL-17 secreting Th17 cells) suggests promotion macrophage infiltration sustained inflammation. In addition MMP13 MMP16, Keap1 was be increased samples. Keap1, repressor master cellular defense against oxidative electrophilic stresses, reported involved imbalance proteolysis lead towards premature aging senescent phenotype endothelial cells. excess might contribute altered proteostasis PIH.